Key result
Exposure of cultured neonatal rat ventricular myocytes to hyperkalemic medium increased Na/K-ATPase alpha1 and alpha3 mRNA expression by 1.9- and 1.5-fold (p<0.01), an effect attenuated by T3.
Population
Cultured neonatal rat atrial and ventricular myocytes
Comparison
Hyperkalemic medium with triiodo-L-thyronine at… vs Hyperkalemic medium without T3, and normal…
Design
Preclinical
Authors
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Should not alter practice; leaves open T3 modulation of cardiac Na/K-ATPase in humans.
Effect estimate: 1.9- and 1.5-fold increase
p-value: p=<0.01
In cultured neonatal rat myocytes, hyperkalemia increases Na/K-ATPase expression, an effect that is modulated by thyroid hormone (T3) in an isoform- and chamber-specific manner.
Yalçın et al. (1999) studied Cultured neonatal rat atrial and ventricular myocytes. Hyperkalemic medium and T3 vs. Absence of T3 was evaluated on Expression of Na/K-ATPase catalytic subunit mRNAs (alpha1 and alpha3 isoforms) (1.9- and 1.5-fold increase, p=<0.01). Exposure of cultured neonatal rat ventricular myocytes to hyperkalemic medium increased Na/K-ATPase alpha1 and alpha3 mRNA expression by 1.9- and 1.5-fold (p<0.01), an effect attenuated by T3.
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