Expression of miR-146a-5p was significantly upregulated in spontaneously hypertensive rats compared to normotensive controls and positively associated with indices of concentric left ventricular hypertrophy.
p-value: p=<0.0001
We investigated roles of microRNAs-146a-5p, -155-5p, and -29b-5p in development of cardiac hypertrophy and dysfunction in SHRs. We showed that miR-146a-5p expression was upregulated in SHRs and positively associated with indices of concentric LVH and diastolic dysfunction, potentially as countermechanism in response to myocardial inflammation, whereas miR-155-5p was expressed in a manner consistent with sexual dimorphism. Our data may offer novel insights on involvement of miRNAs in myocardial inflammation in hypertension-induced cardiac hypertrophy and dysfunction.
Mkhize et al. (Tue,) conducted a other in Hypertension-induced cardiac hypertrophy and dysfunction (n=32). Spontaneously hypertensive rats (SHR) vs. Normotensive Wistar Kyoto rats (WKY) was evaluated on Left ventricular tissue miR-146a-5p expression (p=<0.0001). Expression of miR-146a-5p was significantly upregulated in spontaneously hypertensive rats compared to normotensive controls and positively associated with indices of concentric left ventricular hypertrophy.
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