What question did this study set out to answer?

To evaluate the relationship between the proportion of vigorous physical activity relative to total moderate-to-vigorous activity and the risks of incident cardiovascular disease and all-cause mortality.

December 13, 2022International Journal of Behavioral Nutrition and Physical ActivityOpen Access

Associations of physical activity intensity with incident cardiovascular diseases and mortality among 366,566 UK adults

Q: What are the key findings of this study?

Engaging in up to 30% of vigorous physical activity relative to total moderate-to-vigorous physical activity was associated with a 12% lower risk of incident cardiovascular disease compared to no VPA.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Without baseline cardiovascular disease (n=366566). Intervention: Vigorous physical activity (VPA) proportion vs. 0% VPA (no vigorous physical activity). Primary outcome: Incident cardiovascular disease (HR 0.88, 95% CI 0.86-0.91, p=<0.001).

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Key result

Vigorous activity up to 30% of total MVPA is linked to ~12% lower incident CVD risk.

HR 0.88
95% CI 0.86-0.91
P<0.001
n=366,566

Why the study?

The associations of the proportion of vigorous physical activity to moderate to vigorous physical activity with incident cardiovascular disease and all-cause mortality are unclear.

Does engaging in a higher proportion of vigorous physical activity reduce the risk of incident cardiovascular disease and all-cause mortality in adults without baseline CVD?

Population

366,566 UK Biobank participants aged 40-69 years without baseline CVD

Comparison

Different proportions of vigorous physical activity to moderate to vigorous physical activity vs no vigorous physical activity

Design

Prospective cohort study

Follow-up

Median 11.8 years

Authors

XMXuanwen MuHuazhong University of Science and Technology SLShuangyan LiuHuazhong University of Science and Technology MFMingjian FuHuazhong University of Science and Technology

Discussion

Member takes

Implication

May support including vigorous bouts in MVPA plans; extends observational data but leaves causal confirmation open.

Key Points

To evaluate the relationship between the proportion of vigorous physical activity relative to total moderate-to-vigorous activity and the risks of incident cardiovascular disease and all-cause mortality.
Analyzed 366,566 participants aged 40–69 years without prior cardiovascular disease from the UK Biobank cohort between 2006 and 2010.
Employed Cox proportional hazards regression models to calculate hazard ratios and 95% confidence intervals across a median follow-up period of 11.8 years.
Across 31,894 incident cardiovascular disease cases and 19,823 deaths, engaging in 0%–30% vigorous activity compared to none was associated with lower risks of incident cardiovascular disease (HR, 0.88; 95% CI, 0.86–0.91) and all-cause mortality (HR, 0.81; 95% CI, 0.78–0.84).
The greatest risk reduction occurred when vigorous physical activity comprised approximately 30% of total moderate-to-vigorous physical activity (P < 0.001).
Participants performing 150–300 min/week of moderate activity alongside ≥150 min/week of vigorous activity achieved the lowest risk of cardiovascular disease (HR, 0.87; 95% CI, 0.79–0.95) and all-cause mortality (HR, 0.71; 95% CI, 0.63–0.80).

Study Design

Type

Cohort (n=366,566)

Multicenter

Yes

Structured PICO

Does engaging in a higher proportion of vigorous physical activity reduce the risk of incident cardiovascular disease and all-cause mortality in adults without baseline CVD?

Population

366,566 UK adults (aged 40-69 years) without baseline cardiovascular disease from the UK biobank, mean age 56.0

Intervention

Engaging in vigorous physical activity (VPA), specifically 0%-30% of VPA to moderate to vigorous physical activity (MVPA), or 150-300 min/week of MPA and ≥ 150 min/week of VPA

Comparator

No vigorous physical activity (VPA), or lowest levels of MVPA (MPA 0-150 min/week; VPA 0-75 min/week)

Outcome

Incident cardiovascular disease (CVD) and all-cause mortality at median 11.8 years follow-uphard clinical

Main Result

Effect estimate: HR 0.88 (95% CI 0.86-0.91)

Absolute Event Rate: 73% vs 90%

p-value: p=<0.001

Engaging in vigorous physical activity, particularly around 30% of total moderate-to-vigorous physical activity, is associated with significant reductions in incident CVD and all-cause mortality.

Limitations

Information on physical activity was obtained once by self-report and might be inaccurate in differentiating intensities
The UK Biobank sample was not representative of the UK population and more than 90% of participants were white
Possibility of reverse causation existed because participants with underlying diseases were less likely to perform VPA

Cite This Study

Mu et al. (2022) conducted a cohort in Without baseline cardiovascular disease (n=366,566). Vigorous physical activity (VPA) proportion vs. 0% VPA (no vigorous physical activity) was evaluated on Incident cardiovascular disease (HR 0.88, 95% CI 0.86-0.91, p=<0.001). Engaging in up to 30% of vigorous physical activity relative to total moderate-to-vigorous physical activity was associated with a 12% lower risk of incident cardiovascular disease compared to no VPA.

synapsesocial.com/papers/6a0e8b237b06478e784c4de8 https://doi.org/10.1186/s12966-022-01393-y

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Associations of physical activity intensity with incident cardiovascular diseases and mortality among 366,566 UK adults

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Associations of physical activity intensity with incident cardiovascular diseases and mortality among 366,566 UK adults

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider