Key result
His bundle pacing shows no benefit over conventional CRT for death or worsening heart failure.
Why the study?
His bundle pacing alone or with coronary sinus pacing was proposed as an alternative to conventional CRT, but controlled studies assessing clinical outcomes were lacking.
Does His bundle pacing (alone or with LV pacing) reduce death or heart failure events compared to conventional CRT in patients with heart failure?
Comparison
HBP alone or HBP+LV vs conventional CRT
Design
Single-center propensity-score matched case-control study
Follow-up
Mean of 9.6 months
Authors
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His bundle pacing was not associated with better outcomes than conventional CRT; leaves open whether randomized trials will show benefit despite shorter QRS.
Case-Control (n=54)
No
Does His bundle pacing (alone or with LV pacing) reduce death or heart failure events compared to conventional CRT in patients with heart failure?
Absolute Event Rate: 11% vs 15%
p-value: p=0.58
His bundle pacing achieves shorter QRS duration than conventional CRT but does not significantly improve clinical outcomes in this small propensity-matched cohort.
Sénès et al. (2021) conducted a case-control in Heart failure (n=54). His bundle pacing (HBP) alone or with coronary sinus pacing (HBP+LV) vs. Conventional cardiac resynchronization therapy (CRT) was evaluated on Composite clinical outcome of death, hospitalization for HF or worsening HF (p=0.58). His bundle pacing (alone or with coronary sinus pacing) did not significantly improve death, HF hospitalization, or worsening HF compared to conventional CRT (11% vs 15%, p=0.58).
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