Key result
CRT reduces mechanical dyssynchrony to improve mitral regurgitation whereas RVP worsens valvular function.
This review summarizes the electromechanical consequences of ventricular pacing, emphasizing its impact on mitral valve function and the potential of alternative pacing sites to improve CRT efficacy.
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May warrant caution with RV apical pacing in MR patients; leaves open optimal site selection pending prospective trials.
Ebrille et al. (2016) conducted a review in Ventricular pacing-induced dyssynchrony and valvular dysfunction. Cardiac resynchronization therapy and alternative pacing sites vs. Right ventricular apical pacing was evaluated. Right ventricular apical pacing induces electromechanical dyssynchrony that can worsen valvular function, while cardiac resynchronization therapy may ameliorate mechanical dyssynchrony and improve mitral regurgitation.
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