Prophylactic parenteral cephaloridine (n=376) significantly reduced the rate of wound infection across most types of general surgical operations compared to untreated controls (n=386).
RCT (n=762)
random
Does prophylactic parenteral cephaloridine reduce the rate of wound infection in general surgical wounds?
Three parenteral doses of prophylactic cephaloridine significantly reduce the rate of surgical wound infections in most general surgical procedures.
Abstract In a series of 762 general surgical wounds 376 were selected at random to receive three parenteral doses of cephaloridine and 386 remained as untreated controls. In all types of operation, with the exception of wounds in the lower extremities associated with arterial surgery, the rate of wound infection was lowered by the prophylactic use of cephaloridine. The results were statistically significant for total wounds, clean wounds, total contaminated wounds, and contaminated wounds other than in colorectal surgery. We therefore recommend the routine use of three doses of cephaloridine.
Evans et al. (Fri,) conducted a rct in general surgical wounds (n=762). cephaloridine vs. untreated controls was evaluated on wound infection. Prophylactic parenteral cephaloridine (n=376) significantly reduced the rate of wound infection across most types of general surgical operations compared to untreated controls (n=386).