Key result
Transthoracic tissue Doppler echocardiography demonstrated that left atrial appendage relaxation velocity significantly declines with aging in healthy subjects (r = -0.48, P < 0.001).
Why the study?
Can transthoracic tissue Doppler echocardiography reliably assess left atrial appendage function and its changes with aging?
Population
155 subjects (45 consecutive patients with heart disease and 110 healthy individuals)
Comparison
Transthoracic tissue Doppler echocardiography to… vs Transesophageal echocardiography
Design
Cross-sectional
Authors
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Supports noninvasive TTE assessment of LAA function; hypothesis-generating for outcomes and should not yet change practice.
Cross-Sectional (n=155)
Can transthoracic tissue Doppler echocardiography reliably assess left atrial appendage function and its changes with aging?
Effect estimate: r = 0.97 for contraction, r = 0.95 for relaxation
p-value: p=<0.001
Transthoracic tissue Doppler echocardiography is a feasible and reliable non-invasive method to assess left atrial appendage function, revealing that LAA relaxation impairs with aging.
Yoshida et al. (2010) conducted a cross-sectional in Heart disease and healthy individuals (n=155). Transthoracic tissue Doppler echocardiography (TDE) vs. Transesophageal echocardiography (TEE) was evaluated on Correlation of LAA wall motion velocity during contraction and relaxation between TTE and TEE, and changes with aging (r = 0.97 for contraction, r = 0.95 for relaxation, p=<0.001). Transthoracic tissue Doppler echocardiography demonstrated that left atrial appendage relaxation velocity significantly declines with aging in healthy subjects (r = -0.48, P < 0.001).
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