Key result
Patients with chronic heart failure stopped by fatigue versus breathlessness during exercise testing showed no significant difference in peak oxygen consumption (15.66 vs 15.13 ml/kg/min; P=ns).
Why the study?
Are there differences in exercise performance, ventilatory response, or left ventricular parameters between chronic heart failure patients whose exercise is limited by fatigue versus breathlessness?
Observational (n=222)
Are there differences in exercise performance, ventilatory response, or left ventricular parameters between chronic heart failure patients whose exercise is limited by fatigue versus breathlessness?
Absolute Event Rate: 15.66% vs 15.13%
p-value: p=ns
In patients with chronic heart failure, exercise limitation due to fatigue versus breathlessness is not associated with differences in exercise performance, ventilatory response, or left ventricular function, suggesting a unified pathophysiology for these symptoms.
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Fatigue- versus breathlessness-limited HF patients show similar exercise capacity; hypothesis-generating for unified mechanisms, should not yet change practice.
Clark et al. (1995) conducted an observational in chronic heart failure (n=222). Exercise limitation by fatigue vs. Exercise limitation by breathlessness was evaluated on peak oxygen consumption (ml.kg-1.min-1) (p=ns). Patients with chronic heart failure stopped by fatigue versus breathlessness during exercise testing showed no significant difference in peak oxygen consumption (15.66 vs 15.13 ml/kg/min; P=ns).
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