Key result
CHF linked to ~54% higher ventilatory response and reduced maximal VO2 versus controls.
Why the study?
Do ventilatory and gas exchange abnormalities contribute to exercise limitation in patients with chronic heart failure?
Population
30 patients with exertional breathlessness due to chronic heart failure and 30 controls (n=60)
Comparison
Exercise testing using continuous transcutaneous… vs 30 controls
Design
Case-control
Authors
Loading...
May link ventilatory inefficiency to exercise limitation in heart failure; hypothesis-generating and requires prospective validation.
Case-Control (n=60)
Do ventilatory and gas exchange abnormalities contribute to exercise limitation in patients with chronic heart failure?
Absolute Event Rate: 39.9% vs 25.9%
Patients with chronic heart failure exhibit a significant degree of wasted ventilation and increased ventilatory response on exertion, which contributes to their exercise limitation.
Al-Rawas et al. (1995) conducted a case-control in Chronic heart failure (n=60). Chronic heart failure vs. Controls was evaluated on Ventilatory response (minute ventilation/carbon dioxide production [V'E/V'CO2]). Patients with chronic heart failure exhibited a significantly increased ventilatory response (39.9 vs 25.9) and reduced maximal oxygen consumption (45% vs 87% predicted) compared to controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: