Key result
Left atrial linear cryoablation achieved a higher rate of sinus rhythm off antiarrhythmic drugs at 2 years compared to pulmonary vein cryoisolation alone (57% vs 20%) in patients with permanent AF.
Why the study?
Does left atrial linear cryoablation improve the persistence of sinus rhythm compared to pulmonary vein cryoisolation alone in patients with permanent atrial fibrillation and valvular heart disease undergoing valve surgery?
Population
105 patients with permanent atrial fibrillation, left atrial dilatation, and valvular heart disease…
Comparison
Left atrial linear cryoablation vs Anatomic cryoisolation of pulmonary veins only
Design
Cohort
Follow-up
2 years
Authors
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May support adjunctive linear ablation in permanent AF valve surgery; hypothesis-generating, needs randomized confirmation.
RCT (n=105)
Does left atrial linear cryoablation improve the persistence of sinus rhythm compared to pulmonary vein cryoisolation alone in patients with permanent atrial fibrillation and valvular heart disease undergoing valve surgery?
Absolute Event Rate: 57% vs 20%
In patients with permanent atrial fibrillation and valvular heart disease undergoing valve surgery, left atrial linear cryoablation is more effective than pulmonary vein isolation alone for maintaining sinus rhythm.
Gaïta et al. (2004) conducted an RCT in Permanent atrial fibrillation and valvular heart disease (n=105). Left atrial linear cryoablation vs. Pulmonary vein cryoisolation alone was evaluated on Persistence of sinus rhythm (SR) off antiarrhythmic drugs (AADs) at 2-year follow-up. Left atrial linear cryoablation achieved a higher rate of sinus rhythm off antiarrhythmic drugs at 2 years compared to pulmonary vein cryoisolation alone (57% vs 20%) in patients with permanent AF.
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