Key result
Hypertensive patients with chest pain and normal coronary angiograms had significantly reduced mid and apical myocardial perfusion reserve index compared to controls (1.71 vs 2.52; P<0.02).
Why the study?
Does well-controlled hypertension in patients with chest pain and normal coronary angiograms impair myocardial perfusion reserve independently of left ventricular hypertrophy?
Population
102 patients with well controlled hypertension, history of chest pain, and normal coronary angiography, and…
Comparison
Myocardial first-pass perfusion cardiovascular… vs Healthy volunteers and internal comparison…
Design
Cross-sectional
Authors
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May indicate microvascular dysfunction in hypertensive angina with normal coronaries; hypothesis-generating and requires prospective validation before practice change.
Observational (n=114)
Does well-controlled hypertension in patients with chest pain and normal coronary angiograms impair myocardial perfusion reserve independently of left ventricular hypertrophy?
Absolute Event Rate: 0.13% vs 0.04%
p-value: p=<0.001
Hypertensive patients with chest pain and normal coronary angiograms have impaired regional myocardial perfusion reserve independent of left ventricular hypertrophy, suggesting microvascular dysfunction as a cause of angina.
Kawecka−Jaszcz et al. (2008) conducted an observational in Arterial hypertension with a history of chest pain and normal coronary angiography (n=114). Cardiovascular magnetic resonance myocardial perfusion imaging vs. Healthy volunteers was evaluated on Baseline myocardial perfusion index (p=<0.001). Hypertensive patients with chest pain and normal coronary angiograms had significantly reduced mid and apical myocardial perfusion reserve index compared to controls (1.71 vs 2.52; P<0.02).
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