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November 1, 2025Physics of Fluids

Structural and hemodynamic analysis for predicting side branch occlusion in coronary bifurcation interventions

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Key result

Narrow bifurcation angles and severe stenosis predict higher side branch occlusion risk via disturbed flow.

Why the study?

Main branch stenting carries a significant risk of side branch occlusion, a complication with irreversible clinical consequences.

Do geometric and pathological factors predict the risk of side branch occlusion during main branch stenting in coronary bifurcations?

Population

Patient-based geometries with side branch occlusion

Comparison

Systematic variation of geometric, pathological, and hemodynamic factors during simulated balloon inflation

Design

Structural and computational fluid dynamics simulation study

Authors

ABAyatollah BayatianPolice DepartmentANAhmad NooraeenSahand University of TechnologyHAHossein ArzaniPolice Department

Discussion

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Implication

Computational modeling reveals that narrow bifurcation angle and higher main branch stenosis severity increase the risk of side branch occlusion during coronary bifurcation stenting.

Structured PICO

Do geometric and pathological factors predict the risk of side branch occlusion during main branch stenting in coronary bifurcations?

P
Population
Patient-based geometries of coronary bifurcations that experienced side branch occlusion (SBO)
I
Intervention
Systematic variation of geometric and pathological factors (bifurcation angle, main branch stenosis severity, free side branch diameter, and plaque morphology) in a structural and hemodynamic computational model simulating balloon inflation
O
Outcome
Risk of side branch occlusion (SBO) assessed via structural deformation and hemodynamic parameters (recirculation zone, oscillatory shear index, wall shear stress)surrogate

Computational modeling reveals that narrow bifurcation angle and higher main branch stenosis severity increase the risk of side branch occlusion during coronary bifurcation stenting.

Cite This Study

Bayatian et al. (2025) studied Coronary bifurcation atherosclerosis. Main branch stenting (computational modeling) was evaluated on Side branch occlusion risk and hemodynamic parameters (disturbed flow, oscillatory shear index, wall shear stress). Computational modeling revealed that narrow bifurcation angle and higher main branch stenosis severity promote disturbed flow and structural deformation, increasing the risk of side branch occlusion.

synapsesocial.com/papers/6a0fa2fb9e54838161fcfbe7https://doi.org/10.1063/5.0293854

Topics

Chronic total occlusion PCIPercutaneous coronary intervention
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