Why the study?
Do superoxide anion scavengers or NAD(P)H oxidase inhibitors reduce collagen production in cardiac fibroblasts?
Population
cardiac fibroblasts
Design
Review
Authors
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Extends mechanistic links between superoxide and cardiac fibroblast collagen production; leaves open clinical translation to antifibrotic therapy.
Do superoxide anion scavengers or NAD(P)H oxidase inhibitors reduce collagen production in cardiac fibroblasts?
Pharmacological intervention with superoxide dismutase mimetics to scavenge superoxide anions may offer a therapeutic approach to reduce myocardial fibrosis in hypertensive heart disease.
Lijnen et al. (2010) studied this question.