Why the study?
Severe tricuspid regurgitation carries high 1-year morbidity and mortality, but long-term cardiovascular risk overall and by subgroups remains unknown.
Population
2379 consecutive patients with new severe TR at a large US tertiary referral center
Comparison
Outcomes compared across TR etiologies and phenoclusters identified by survival trees
Design
Retrospective cohort study
Follow-up
5 years
Authors
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Phenoclustering may refine risk stratification in severe TR; leaves open prospective validation and therapeutic implications.
Phenoclustering using survival tree models, rather than traditional TR etiology, effectively discriminates the high 5-year risk of death and heart failure hospitalization in patients with severe tricuspid regurgitation.
Rao et al. (2023) studied this question.
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