What is the clinical evidence from this study?

Study design: Observational. Population: Healthy individuals (n=33). Intervention: Moderate and vigorous exercise vs. Untrained individuals / Rest. Primary outcome: Volume responses of the right ventricle, left atrium, and right atrium during exercise.

What does this research mean for the field?

Moderate and vigorous exercise decreases right ventricular and right atrial volumes in endurance-trained individuals, whereas these volumes remain unchanged in untrained healthy individuals. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to explore how the four-chambered heart responds to exercise in endurance-trained and untrained healthy individuals while controlling for respiratory influences.

May 22, 2026PLoS ONEOpen Access

Moderate and vigorous exercise is linked to decreased RV and RA volumes only in endurance-trained individuals.

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Why the study?

RV, LA, and RA volume responses during exercise had not been studied simultaneously in the same subject while standardizing for respiratory influences.

Does endurance training alter the dynamic right ventricular and atrial volume responses to exercise in healthy individuals?

Comparison

ET vs UT healthy individuals at rest and during moderate and vigorous exercise

Design

Exercise real-time CMR physiological study

Key result

Moderate and vigorous exercise decreased right ventricular and right atrial volumes in endurance-trained individuals, whereas these volumes remained unchanged in untrained healthy individuals.

Authors

BÖBjörn Östenson EOEllen Ostenfeld JEJonathan Edlund

Discussion

Member takes

Overview

LV volumes decrease during exercise regardless of training status; extends simultaneous four-chamber assessment but leaves open clinical translation.

Key Points

The aim is to explore how the four-chambered heart responds to exercise in endurance-trained and untrained healthy individuals while controlling for respiratory influences.
Twenty endurance-trained and thirteen untrained healthy individuals underwent cardiac magnetic resonance imaging at rest and during exercise.
End-diastolic and end-systolic volumes, stroke volumes, and atrial volumes were measured during these imaging sessions.
Responses were compared between the two groups during both moderate and vigorous exercise.
Left ventricular end-diastolic volume decreased in both groups during exercise.
Right ventricular end-diastolic and end-systolic volumes decreased in endurance-trained individuals but remained unchanged in untrained individuals.
Right atrial maximum volume decreased in endurance-trained individuals during exercise, while untrained individuals showed no changes in atrial volumes.

Study Design

Type

Observational (n=33)

Structured PICO

Does endurance training alter the dynamic right ventricular and atrial volume responses to exercise in healthy individuals?

Population

33 healthy individuals (20 endurance-trained [9 women] and 13 untrained matched for age and sex)

Intervention

Moderate and vigorous exercise evaluated by real-time cardiac magnetic resonance imaging (CMR)

Comparator

Untrained healthy individuals (for group comparison) and resting state (for exercise comparison)

Outcome

Volume responses of the four cardiac chambers (LV and RV end-diastolic and end-systolic volumes, stroke volumes, and maximal/minimal LA and RA volumes) measured at end expirationsurrogate

Endurance-trained individuals exhibit distinct right ventricular and right atrial volume reductions during exercise compared to untrained individuals, highlighting specific right-sided cardiac adaptations to training.

Cite This Study

Östenson et al. (2026) conducted an observational in Healthy individuals (n=33). Moderate and vigorous exercise vs. Untrained individuals / Rest was evaluated on Volume responses of the right ventricle, left atrium, and right atrium during exercise. Moderate and vigorous exercise decreased right ventricular and right atrial volumes in endurance-trained individuals, whereas these volumes remained unchanged in untrained healthy individuals.

synapsesocial.com/papers/6a0ff3d9d674f7c03778cca4 https://doi.org/10.1371/journal.pone.0347745

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May 22, 2026PLoS ONEOpen Access

Moderate and vigorous exercise is linked to decreased RV and RA volumes only in endurance-trained individuals.

View Full Paper

Ask AI

Bookmark

Why the study?

RV, LA, and RA volume responses during exercise had not been studied simultaneously in the same subject while standardizing for respiratory influences.

Does endurance training alter the dynamic right ventricular and atrial volume responses to exercise in healthy individuals?

Comparison

ET vs UT healthy individuals at rest and during moderate and vigorous exercise

Design

Exercise real-time CMR physiological study

Key result

Moderate and vigorous exercise decreased right ventricular and right atrial volumes in endurance-trained individuals, whereas these volumes remained unchanged in untrained healthy individuals.

Authors

BÖBjörn Östenson EOEllen Ostenfeld JEJonathan Edlund

Discussion

Member takes

Overview

LV volumes decrease during exercise regardless of training status; extends simultaneous four-chamber assessment but leaves open clinical translation.

Key Points

The aim is to explore how the four-chambered heart responds to exercise in endurance-trained and untrained healthy individuals while controlling for respiratory influences.
Twenty endurance-trained and thirteen untrained healthy individuals underwent cardiac magnetic resonance imaging at rest and during exercise.
End-diastolic and end-systolic volumes, stroke volumes, and atrial volumes were measured during these imaging sessions.
Responses were compared between the two groups during both moderate and vigorous exercise.
Left ventricular end-diastolic volume decreased in both groups during exercise.
Right ventricular end-diastolic and end-systolic volumes decreased in endurance-trained individuals but remained unchanged in untrained individuals.
Right atrial maximum volume decreased in endurance-trained individuals during exercise, while untrained individuals showed no changes in atrial volumes.

Study Design

Type

Observational (n=33)

Structured PICO

Does endurance training alter the dynamic right ventricular and atrial volume responses to exercise in healthy individuals?

Population

33 healthy individuals (20 endurance-trained [9 women] and 13 untrained matched for age and sex)

Intervention

Moderate and vigorous exercise evaluated by real-time cardiac magnetic resonance imaging (CMR)

Comparator

Untrained healthy individuals (for group comparison) and resting state (for exercise comparison)

Outcome

Volume responses of the four cardiac chambers (LV and RV end-diastolic and end-systolic volumes, stroke volumes, and maximal/minimal LA and RA volumes) measured at end expirationsurrogate

Cite This Study

synapsesocial.com/papers/6a0ff3d9d674f7c03778cca4 https://doi.org/10.1371/journal.pone.0347745

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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