Key result
Transcatheter tricuspid valve replacement using the Edwards Evoque system resulted in immediate and significant improvement of heart failure symptoms, congestion, and kidney and liver function.
Why the study?
Severe tricuspid regurgitation causes heart failure symptoms and end-organ dysfunction, but many patients are considered too high risk for surgery, prompting the development and increased use of transcatheter repair or replacement systems.
Does transcatheter tricuspid valve replacement improve clinical symptoms and end-organ dysfunction in high-risk patients with severe tricuspid regurgitation?
Case Report (n=1)
Does transcatheter tricuspid valve replacement improve clinical symptoms and end-organ dysfunction in high-risk patients with severe tricuspid regurgitation?
TTVR can rapidly improve clinical symptoms and reverse end-organ dysfunction in high-risk elderly patients with severe tricuspid regurgitation.
Hypothesis-generating for rapid recovery after transcatheter tricuspid valve replacement; leaves open confirmation in larger trials.
BACKGROUND: Severe tricuspid regurgitation (TR) is associated with heart failure symptoms and end-organ dysfunction. Many patients are considered too high risk for surgical intervention, prompting the development and increased use of transcatheter valve replacement/repair systems. CASE SUMMARY: We report the case of an 85-year-old White male with symptomatic heart failure and signs of worsening end-organ dysfunction due to torrential TR who underwent transcatheter tricuspid valve replacement (TTVR) using the Edwards Evoque system. After TTVR, the patient experienced immediate and significant improvement of heart failure symptoms. Furthermore, congestion diminished substantially. Additionally, he demonstrated significant improvement of kidney function. Signs of liver congestions also improved rapidly. DISCUSSION: This case demonstrates that treatment of severe TR using a TTVR system, even in an older, high-risk patient, can significantly improve not only clinical symptoms but also end-organ dysfunction. TAKE-HOME MESSAGE: TTVR should be considered in patients with severe TR and end-organ dysfunction.
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Marek‐Iannucci et al. (2026) conducted a case report in Severe tricuspid regurgitation with symptomatic heart failure and end-organ dysfunction (n=1). Transcatheter tricuspid valve replacement (TTVR) using the Edwards Evoque system was evaluated on Improvement of heart failure symptoms and end-organ dysfunction. Transcatheter tricuspid valve replacement using the Edwards Evoque system resulted in immediate and significant improvement of heart failure symptoms, congestion, and kidney and liver function.
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