Key result
Native T1-mapping demonstrated that T1-values at the interventricular insertion regions are significantly increased in precapillary pulmonary hypertension patients and correlate with disease severity.
Why the study?
Does native T1-mapping without contrast agents identify myocardial abnormalities at the interventricular insertion regions in patients with precapillary pulmonary hypertension?
Observational (n=80)
No
Does native T1-mapping without contrast agents identify myocardial abnormalities at the interventricular insertion regions in patients with precapillary pulmonary hypertension?
Native T1-mapping identifies increased T1 values at the interventricular insertion regions in precapillary pulmonary hypertension, correlating with disease severity and offering a contrast-free alternative for myocardial characterization.
Answers are grounded in this paper and cite their sources.
Native T1-mapping may enable contrast-free myocardial assessment in precapillary PH; leaves open validation for risk stratification or monitoring.
Cardiac magnetic resonance imaging of the pressure overloaded right ventricle (RV) of precapillary pulmonary hypertension (PH) patients, exhibits late gadolinium enhancement at the interventricular insertion regions, a phenomenon which has been linked to focal fibrosis. Native T1-mapping is an alternative technique to characterize myocardium and has the advantage of not requiring the use of contrast agents. The aim of this study was to characterize the myocardium of idiopathic pulmonary arterial hypertension (IPAH), systemic scleroderma related PH (PAH-Ssc) and chronic thromboembolic PH (CTEPH) patients using native T1-mapping and to see whether native T1-values were related to disease severity. Furthermore, we compared native T1-values between the different precapillary PH categories. Native T1-mapping was performed in 46 IPAH, 14 PAH-SSc and 10 CTEPH patients and 10 control subjects. Native T1-values were assessed using regions of interest at the RV and LV free wall, interventricular septum and interventricular insertion regions. In PH patients, native T1-values of the interventricular insertion regions were significantly higher than the native T1-values of the RV free wall, LV free wall and interventricular septum. Native T1-values at the insertion regions were significantly related to disease severity. Native T1-values were not different between IPAH, PAH-Ssc and CTEPH patients. Native T1-values of the interventricular insertion regions are significantly increased in precapillary PH and are related to disease severity. Native T1-mapping can be developed as an alternative technique for the characterization of the interventricular insertion regions and has the advantage of not requiring the use of contrast agents.
No takes yet. Share an insight, caveat, or question.
Spruijt et al. (2015) conducted an observational in Precapillary pulmonary hypertension (IPAH, PAH-SSc, CTEPH) (n=80). Native T1-mapping (Cardiac magnetic resonance imaging) vs. Healthy controls and other myocardial regions was evaluated on Native T1-values of the interventricular insertion regions in PH patients (p=<0.05). Native T1-mapping demonstrated that T1-values at the interventricular insertion regions are significantly increased in precapillary pulmonary hypertension patients and correlate with disease severity.
Synapse has enriched 10 related papers. Consider them for comparative context: