Key result
Target-intensity exercise rehabilitation improves cardiopulmonary capacity, FMD, and Lp-PLA2 in a post-PCI patient.
Why the study?
The effects of exercise rehabilitation on cardiopulmonary exercise capacity, oxygen uptake efficiency slope, endothelial function, and Lp-PLA2 had not been observed in CHD patients 3 months after PCI.
Does monitoring exercise rehabilitation with target intensity improve cardiopulmonary exercise capacity, endothelial function, and Lp-PLA2 in a patient with coronary heart disease after twice PCI?
Case Report (n=1)
Does monitoring exercise rehabilitation with target intensity improve cardiopulmonary exercise capacity, endothelial function, and Lp-PLA2 in a patient with coronary heart disease after twice PCI?
Center-based monitoring exercise rehabilitation with target intensity can improve cardiopulmonary exercise capacity and endothelial function in patients with chronic coronary syndrome after complex PCI.
Case-level data suggest monitored exercise rehab may aid post-complex PCI recovery; leaves open generalizability to broader chronic coronary syndrome populations.
RATIONALE: As the core of cardiac rehabilitation (CR), early exercise rehabilitation is beneficial for patients with coronary heart disease (CHD), and center-based CR with target intensity is superior to home-based CR. However, there was no research to observe the effects of exercise rehabilitation on cardiopulmonary exercise capacity, oxygen uptake efficiency slope, endothelial function evaluated as flow-mediated vasodilation (FMD), and blood plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) in CHD patients undergone percutaneous coronary intervention (PCI) for 3 months. PATIENT CONCERNS: A 57-year-old woman had been identified with triple vessel disease and undergone twice PCI for complete revascularization, however, there was no improvement in Lp-PLA2, FMD, and related indicators of cardiopulmonary exercise testing. DIAGNOSIS: Coronary angiography showed an 85% stenosis in the middle left anterior descending artery, an 85% stenosis in the proximity of a thick first-diagonal branch, a long 75 to 85% stenosis in the middle left circumflex artery, and a 90 to 95% stenosis in the proximal. The case was diagnosed as CHD. INTERVENTIONS: The patient obtained optimal medical therapy comprising therapeutic lifestyle changes, and began monitoring exercise rehabilitation with target intensity 3 months after the second PCI in the CR center. OUTCOMES: There were changes in cardiopulmonary exercise capacity, oxygen uptake efficiency slope, FMD, and Lp-PLA2 in the patient with 3 apparent stenotic coronary arteries who was done PCI twice, without or with postoperative exercise rehabilitation, respectively. LESSONS: We proved that monitoring exercise rehabilitation training with target intensity could improve the prognosis of chronic coronary syndrome patients, and it was never too late to do regular exercise rehabilitation.
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Liu et al. (2023) conducted a case report in Coronary heart disease (n=1). Monitoring exercise rehabilitation with target intensity vs. Baseline (without postoperative exercise rehabilitation) was evaluated on Changes in cardiopulmonary exercise capacity, oxygen uptake efficiency slope, FMD, and Lp-PLA2. Monitoring exercise rehabilitation with target intensity improved cardiopulmonary exercise capacity, oxygen uptake efficiency slope, FMD, and Lp-PLA2 in a 57-year-old woman after twice PCI.
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