Key result
Primary gallbladder cancer links to ~16-fold higher cardiovascular mortality risk versus the general population.
Why the study?
As cancer mortality decreases in gallbladder cancer, cardiovascular mortality has become the main cause of non-cancer death, but cardiovascular mortality risk in primary gallbladder cancer required determination.
What is the risk of cardiovascular mortality in patients with primary gallbladder cancer compared to the general population?
Population
5925 patients diagnosed with primary gallbladder cancer in the SEER database
Comparison
Primary gallbladder cancer patients vs general United States population
Design
Registry-based retrospective cohort study using competing risks analysis
Authors
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May support CV surveillance in gallbladder cancer; leaves open whether interventions improve outcomes.
Observational (n=5,925)
Yes
What is the risk of cardiovascular mortality in patients with primary gallbladder cancer compared to the general population?
Effect estimate: SMR 15.84 (95% CI 15.83-15.85)
Absolute Event Rate: 4101.7% vs 263.1%
Patients with primary gallbladder cancer have a substantially higher risk of cardiovascular mortality compared to the general population, underscoring the need for cardioprotective strategies in this population.
Chen et al. (2022) conducted an observational in Primary gallbladder cancer (n=5,925). Primary gallbladder cancer vs. General United States population was evaluated on Cardiovascular mortality (SMR 15.84, 95% CI 15.83-15.85). Patients with primary gallbladder cancer had a significantly higher risk of cardiovascular mortality compared to the general population, with a standardized mortality rate of 15.84.
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