What question did this study set out to answer?

The study aims to explore if structural changes in the myocardium during hibernation and atrial fibrillation are indicative of apoptosis.

September 1, 1999Cardiovascular ResearchOpen Access

Cardiomyocyte remodelling during myocardial hibernation and atrial fibrillation: prelude to apoptosis

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The study aims to explore if structural changes in the myocardium during hibernation and atrial fibrillation are indicative of apoptosis.
Analyzed myocardial biopsies from 28 patients with chronic hibernating myocardium and heart samples from 13 goats with atrial fibrillation.
Used light and electron microscopy, terminal deoxynucleotidyl transferase nick end-labelling, and immunohistochemistry to assess apoptosis.
Excluded infarcted areas to prevent false positives in apoptosis identification.
No apoptotic nuclei were found in normal or dedifferentiated cardiomyocytes under electron microscopy.
The end-labelling assay showed no cardiomyocytes with damaged DNA.
Minimal expression of Bcl-2, P53, and PCNA indicated a lack of apoptotic threat or DNA damage.

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Dedifferentiation, not apoptosis, drives remodeling in hibernation and AF; leaves open targeted interventions pending prospective validation.

G Dispersyn (1999) studied this question.

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Dedifferentiation, not apoptosis, drives remodeling in hibernation and AF; leaves open targeted interventions pending prospective validation.