Key result
Cardiac fibroblasts in the rabbit sinoatrial node form a coupled network of cells expressing connexin40 and connexin45, which may be functionally linked to myocytes via gap junctions.
Population
Rabbit sinoatrial node tissue (in situ and explants)
Design
Preclinical
Authors
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Challenges traditional electrical isolation of sinoatrial node myocytes; leaves open whether fibroblast coupling modulates pacemaker function.
Cardiac fibroblasts in the rabbit sinoatrial node form a coupled network via connexin40 and connexin45 that may functionally link to myocytes.
Camelliti et al. (2004) studied Rabbit sinoatrial node fibroblast network. In situ detection of connexins and dye transfer was evaluated on Ability of fibroblasts to form gap junctions in vivo. Cardiac fibroblasts in the rabbit sinoatrial node form a coupled network of cells expressing connexin40 and connexin45, which may be functionally linked to myocytes via gap junctions.
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