Key result
Manual-traced and edge-detected common carotid artery intima-media thickness were associated with incident PAD.
Why the study?
Common carotid artery intima-media thickness is associated with coronary heart disease, but its association with incident peripheral artery disease is poorly studied.
Is common carotid artery intima-media thickness associated with incident peripheral artery disease?
Cohort (n=5,467)
Is common carotid artery intima-media thickness associated with incident peripheral artery disease?
Both manual-traced and edge-detected common carotid artery intima-media thickness are significantly associated with the development of incident peripheral artery disease.
Answers are grounded in this paper and cite their sources.
CCA IMT was associated with incident PAD; hypothesis-generating and should not yet change practice.
Common carotid artery (CCA) intima-media thickness (IMT) is associated with coronary heart disease and can be measured on ultrasound images either by hand or with an automated edge detector. The association of CCA IMT with incident peripheral artery disease (PAD) is poorly studied. We studied 5467 participants of the Multi-Ethnic Study of Atherosclerosis composed of non-Hispanic white, Chinese, Hispanic, and African American participants with a mean age of 61.9 years (47.8% men). Framingham Risk Factors, manual-traced IMT (mt-IMT), and edge-detected IMT (ed-IMT) were entered into multivariable Cox proportional hazards models with incident PAD as the outcome. There were 87 events during a median follow-up of 12.2 years. In fully adjusted models and expressing the hazard ratios (HR) as an increment in SD values, both mt-IMT and ed-IMT were significantly associated with incident PAD: HR 1.36 (95% CI: 1.15, 1.61) and 1.29 (95% CI: 1.04, 1.60), respectively. We conclude that ed- and mt-CCA IMT measurements are associated with incident PAD. ClinicalTrials.gov Identifier: NCT00063440
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Polak et al. (2019) conducted a cohort in incident peripheral artery disease (PAD) (n=5,467). manual-traced IMT (mt-IMT) and edge-detected IMT (ed-IMT) was evaluated on incident PAD (HR 1.36 (mt-IMT), HR 1.29 (ed-IMT), 95% CI 1.15-1.61 (mt-IMT), 1.04-1.60 (ed-IMT)). Manual-traced and edge-detected common carotid artery intima-media thickness were associated with incident PAD.
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