December 1, 1997Journal of Hypertension
Relationships between changes in left ventricular mass and in clinic and ambulatory blood pressure in response to antihypertensive therapy
Key result
Changes in left ventricular mass after 6 months of antihypertensive therapy were significantly correlated with changes in average 24-hour systolic blood pressure (r = 0.45, P < 0.001).
Why the study?
Do changes in clinic and ambulatory blood pressure correlate with changes in left ventricular mass in patients with essential hypertension receiving antihypertensive therapy?
Population
54 patients with essential hypertension (World Health Organization stages I-II)
Comparison
6 months of treatment with one or a combination… vs Baseline (after a placebo run-in period)
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Implication
Ambulatory BP monitoring may better track LV mass changes than clinic readings; leaves open whether it improves outcomes in hypertension.
Study Design
Type
Observational (n=54)
Structured PICO
Do changes in clinic and ambulatory blood pressure correlate with changes in left ventricular mass in patients with essential hypertension receiving antihypertensive therapy?
P
Population
54 patients with essential hypertension (World Health Organization stages I-II)
I
Intervention
6 months of treatment with one or a combination of two first-line antihypertensive drugs
C
Comparator
Baseline (after a placebo run-in period)
O
Outcome
Relationships between changes in left ventricular mass and changes in conventional and automated measurements of clinic blood pressure, average 24 h ambulatory blood pressure and daytime and night-time blood pressuressurrogate
Main Result
Effect estimate: r = 0.45
p-value: p=<0.001
Changes in 24-hour ambulatory blood pressure provide additional predictive value over clinic blood pressure for treatment-induced changes in left ventricular mass in hypertensive patients.
Cite This Study
Fagard et al. (1997) conducted an observational in essential hypertension (n=54). antihypertensive therapy (one or two first-line drugs) was evaluated on correlation between changes in left ventricular mass and changes in average 24 h systolic blood pressure (r = 0.45, p=<0.001). Changes in left ventricular mass after 6 months of antihypertensive therapy were significantly correlated with changes in average 24-hour systolic blood pressure (r = 0.45, P < 0.001).