Key result
No single ECG parameter was an independent predictor of CRT response, though higher R wave amplitude in V6, higher R/S ratio in V6, and higher (S1+R6)-(S6+R1) may predict likelihood of response.
Why the study?
Do specific baseline electrocardiographic parameters predict clinical response to cardiac resynchronization therapy?
Observational (n=102)
Do specific baseline electrocardiographic parameters predict clinical response to cardiac resynchronization therapy?
Specific baseline ECG parameters, including R wave amplitude in V6 and R/S ratio, may help identify patients more likely to respond to cardiac resynchronization therapy.
Baseline ECG parameters should not guide CRT selection; hypothesis-generating for V6 measures pending prospective validation.
INTRODUCTION: Although strict selection criteria are used to select patients for cardiac resynchronisation therapy, up to 30% of patients do not have a positive clinical response. PATIENTS: A total of 102 consecutive patients who had biventricular pacemaker/defibrillator (CRT-P or CRT-D) implanted were enrolled in this prospective observational study. RESULTS: During the average follow-up period of 24.3 months 5 patients died and 17 (16.7%) patients were hospitalised with the symptoms of heart failure; 75 (73.5%) patients were responders based on the previously defined criteria. Responders in the group of LBBB patients kept the significant difference in a computed variable (S1 + R6) - (S6 + R1) and R6/S6 ratio. Responders in non-LBBB patients kept the significant difference only in the height of R waves in V6. The R6/S6 ratio tended to be higher, but it did not reach a statistical significance. CONCLUSION: None of the tested ECG parameters stands out as an independent predictor of response to cardiac resynchronisation therapy, but some of them were different in responder-compared to the non-responder group. The amplitude of R wave in V6, higher R/S ratio in V6 and higher computed variable (S1 + R6) - (S6 + R1) may predict the likelihood of response to CRT therapy in both LBBB-patients and non-LBBB patients.
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Poposka et al. (2018) conducted an observational in Heart failure requiring cardiac resynchronization therapy (n=102). Electrocardiographic parameters was evaluated on Clinical response to cardiac resynchronization therapy. No single ECG parameter was an independent predictor of CRT response, though higher R wave amplitude in V6, higher R/S ratio in V6, and higher (S1+R6)-(S6+R1) may predict likelihood of response.
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