Why the study?
Does continuous intravenous norepinephrine therapy reduce mortality in patients with shock accompanying myocardial infarction?
Does continuous intravenous norepinephrine therapy reduce mortality in patients with shock accompanying myocardial infarction?
Continuous intravenous norepinephrine therapy may reduce mortality in cardiogenic shock following myocardial infarction, though it carries risks of severe arrhythmias.
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Supports norepinephrine in MI shock; provides first RCT evidence of mortality benefit.
A clinical study is presented of the influence of continuous intravenous norepinephrine therapy upon shock accompanying myocardial infarction. The significant reduction in immediate and eventual mortality rates usually associated with this condition are discussed. Complications are defined, and a possible first reported instance is presented of ventricular tachycardia developing in the presence of complete heart block during the administration of large doses of norepinephrine.
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Sampson et al. (1954) studied this question.
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