What does this research mean for the field?

Oxygen supply directly determines the energy state, including phosphocreatine levels, lactate release, and glucose uptake, in both contracting and recovering skeletal muscles. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1985AJP Heart and Circulatory Physiology

Oxygen dependence of energy metabolism in contracting and recovering rat skeletal muscle

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Why the study?

Does oxygen delivery correlate with energy metabolism and fatigue in contracting and recovering rat skeletal muscle?

Population

Perfused rat hindlimb muscles (soleus and gastrocnemius)

Design

Preclinical

Authors

JIJ. P. IdstromAstraZeneca (Sweden)VSV. Harihara SubramanianJohnson Foundation BCB. ChanceUniversity City Science Center

Discussion

Member takes

Implication

Should not alter clinical oxygen strategies; leaves open translation of oxygen-energy correlations to human skeletal or cardiac muscle.

Structured PICO

Does oxygen delivery correlate with energy metabolism and fatigue in contracting and recovering rat skeletal muscle?

Population

Perfused rat hindlimb muscles (soleus and gastrocnemius)

Intervention

Varying levels of oxygen delivery

Outcome

Energy metabolism parameters (oxygen consumption, lactate release, glucose uptake, intramuscular concentrations of phosphocreatine, lactate, glycogen, and PCr/Pi ratio)surrogate

This preclinical study demonstrates a causal relationship between oxygen supply and the energy state in contracting and recovering skeletal muscles.

Cite This Study

Idstrom et al. (1985) studied this question.

synapsesocial.com/papers/6a1573e1814bf8ec9a4e9c22 https://doi.org/10.1152/ajpheart.1985.248.1.h40

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Oxygen dependence of energy metabolism in contracting and recovering rat skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Oxygen dependence of energy metabolism in contracting and recovering rat skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider