March 1, 2018Journal of Applied PhysiologyOpen Access

Oxygen dependence of respiration in rat spinotrapezius muscle contracting at 0.5–8 twitches per second

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Population

Rat spinotrapezius muscle

Comparison

Electrical stimulation at rates from 0.5 to 8 Hz vs Rest (basal workload)

Design

Preclinical

Authors

AGAleksander S. GolubGenesis Biotechnologies (United States)SDSami C. DodhyVirginia Commonwealth University RPRoland N. PittmanVirginia Commonwealth University Medical Center

Discussion

Member takes

Implication

Provides in situ Po2-VO2 data across metabolic rates; leaves open translation to human muscle oxygenation.

Structured PICO

Population

Rat spinotrapezius muscle

Intervention

Electrical stimulation at rates from 0.5 to 8 Hz

Comparator

Rest (basal workload)

Outcome

Rate of O2 consumption (V̇o2) and O2 tension (Po2)surrogate

The sigmoidal shape of curves describing oxygen dependence of muscle respiration varies from basal to maximal workload, and the oxygen supply/consumption system can be modeled as an inverting transistor amplifier.

Cite This Study

Golub et al. (2018) studied this question.

synapsesocial.com/papers/6a6fc4a4660549caf2c451ab https://doi.org/10.1152/japplphysiol.01136.2016

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Oxygen dependence of respiration in rat spinotrapezius muscle contracting at 0.5–8 twitches per second

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Oxygen dependence of respiration in rat spinotrapezius muscle contracting at 0.5–8 twitches per second

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider