Adherence to Medication According to Sex and Age in the CHARM Programme
Key result
Female sex was associated with slightly lower medication adherence compared to male sex (87.3% vs. 89.8%, P=0.002) in patients with heart failure, despite women having lower all-cause mortality.
Why the study?
Are sex and age associated with medication adherence in patients with symptomatic heart failure?
Population
7,599 patients with symptomatic heart failure from the CHARM trial
Design
Cohort
Authors
Discussion
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Member takes
Implication
May warrant adherence monitoring in women with HF; leaves open whether sex-specific interventions affect outcomes.
Study Design
Type
Observational (n=7,599)
Structured PICO
Are sex and age associated with medication adherence in patients with symptomatic heart failure?
P
Population
7,599 patients with symptomatic heart failure from the CHARM trial
O
Outcome
Medication adherence (measured as the proportion of time patients took more than 80% of study medication)
Main Result
Absolute Event Rate: 87.3% vs 89.8%
p-value: p=0.002
In patients with symptomatic heart failure, women demonstrate slightly lower medication adherence than men, highlighting a potential area for targeted intervention despite their lower overall mortality.
Cite This Study
Granger et al. (2009) conducted an observational in Heart failure (n=7,599). Female sex vs. Male sex was evaluated on Medication adherence (proportion of time taking >80% of study medication) (p=0.002). Female sex was associated with slightly lower medication adherence compared to male sex (87.3% vs. 89.8%, P=0.002) in patients with heart failure, despite women having lower all-cause mortality.