Key result
Complete revascularization with percutaneous coronary intervention reduced the 30-day composite endpoint of death, non-fatal MI, or unplanned revascularization by 69% (HR 0.31) compared to incomplete revascularization in patients with multivessel CAD and NSTE-ACS.
Why the study?
Does complete revascularization with percutaneous coronary intervention improve the composite of death, nonfatal MI, or unplanned revascularization in patients with multivessel CAD presenting with NSTE-ACS?
Observational (n=695)
No
Does complete revascularization with percutaneous coronary intervention improve the composite of death, nonfatal MI, or unplanned revascularization in patients with multivessel CAD presenting with NSTE-ACS?
In patients with multivessel CAD presenting with NSTE-ACS, complete revascularization during the index hospitalization is associated with a significantly lower 12-month risk of the composite of death, MI, or unplanned revascularization compared to incomplete revascularization.
Answers are grounded in this paper and cite their sources.
May support complete revascularization in multivessel NSTE-ACS; leaves open need for randomized confirmation.
INTRODUCTION: The clinical significance of complete revascularization with percutaneous coronary intervention (CR-PCI) in patients with non-ST-segment acute coronary syndrome (NSTE-ACS) remains uncertain. AIM: To evaluate the impact of CR-PCI during index hospitalization on short and long-term incidence of death and composite endpoint among patients with multivessel coronary artery disease (CAD) presenting with NSTE-ACS. MATERIAL AND METHODS: = 558) (incomplete revascularization). CONCLUSIONS: In patients with multivessel CAD and NSTE-ACS, CR-PCI during index hospitalization was independently associated with improved early and long-term prognosis without significant differences in periprocedural outcomes in comparison to IR-PCI.
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Hawranek et al. (2018) conducted an observational in Multivessel coronary artery disease presenting with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) (n=695). Complete revascularization with percutaneous coronary intervention (CR-PCI) vs. Incomplete revascularization (IR-PCI) was evaluated on 30-day composite of all-cause death, non-fatal MI, or ACS-driven unplanned revascularization (HR 0.31, 95% CI 0.12-0.87, p=0.025). Complete revascularization with percutaneous coronary intervention reduced the 30-day composite endpoint of death, non-fatal MI, or unplanned revascularization by 69% (HR 0.31) compared to incomplete revascularization in patients with multivessel CAD and NSTE-ACS.
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