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Family history of early angina signals elevated CAD risk in relatives; leaves open whether genetic or environmental factors drive regional differences.
The occurrence of coronary artery disease and its risk factors were assessed in 560 relatives of 104 men who developed angina pectoris before the age of 56 and in 498 relatives of 94 controls in two geographical areas, one with a moderate (South Finland) and another with a high (East Finland) incidence of coronary artery disease.
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Rissanen et al. (1977) studied this question.
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