What question did this study set out to answer?

To evaluate the relationship between serum lipid and apolipoprotein profiles and the occurrence of a first acute myocardial infarction in women under 55 years of age.

November 1, 1988Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Serum lipids and apolipoprotein levels in women with acute myocardial infarction.

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Authors

SJS. JohanssonAstraZeneca (Sweden)GBGöran BondjersUniversity of Gothenburg GFGunnar FagerAstraZeneca (Sweden)

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Implication

Case-control study finds elevated triglycerides and apolipoprotein E independently link to myocardial infarction in young women, highlighting lipid risk factors beyond total cholesterol.

Key Points

To evaluate the relationship between serum lipid and apolipoprotein profiles and the occurrence of a first acute myocardial infarction in women under 55 years of age.
Followed a population base covering more than 150,000 person-years of women younger than 55 years old, identifying 61 survivors of a first acute myocardial infarction (AMI).
Compared 59 AMI survivors with a random control sample from the same population to assess serum lipids, apolipoproteins A-I, A-II, B, and E, blood pressure, and smoking status.
Infarction patients had significantly higher mean levels of serum cholesterol, triglycerides, apo B, and apo E, but significantly lower levels of HDL cholesterol and apo A-I compared to controls.
Multivariate analysis showed age, smoking, hypertension history, high triglycerides, high apo E, and low apo A-I were independently associated with infarction, placing 60% of cases versus 11% of controls in the highest risk quartile.
High serum triglycerides were strongly associated with infarction in this cohort of younger women, whereas total serum cholesterol did not remain an independent risk factor.

Cite This Study

Johansson et al. (1988) studied this question.

synapsesocial.com/papers/6a15da7dbdb7c256665226e4 https://doi.org/10.1161/01.atv.8.6.742

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Implication

Case-control study finds elevated triglycerides and apolipoprotein E independently link to myocardial infarction in young women, highlighting lipid risk factors beyond total cholesterol.

Serum lipids and apolipoprotein levels in women with acute myocardial infarction.

Discussion

Member takes

Implication

Key Points

Cite This Study

Serum lipids and apolipoprotein levels in women with acute myocardial infarction.

Discussion

Member takes

Implication

Key Points

Cite This Study

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