Key result
Multipoint pacing with fused AV delay is linked to improved acute dp/dt versus single atrial pacing.
Why the study?
One-third of heart failure patients do not respond to CRT, and the combined effect of multipoint pacing and fused AV delay on acute hemodynamics was unknown.
Does the combination of multipoint pacing and fused AV delay improve acute hemodynamics in patients undergoing cardiac resynchronization therapy?
Observational (n=52)
Does the combination of multipoint pacing and fused AV delay improve acute hemodynamics in patients undergoing cardiac resynchronization therapy?
p-value: p=< 0.001
The combination of multipoint pacing and fused AV delay provides additional acute hemodynamic benefits in patients receiving cardiac resynchronization therapy.
May enhance CRT optimization; leaves open whether acute dp/dt gains improve clinical outcomes.
Background: Cardiac resynchronization therapy (CRT) is an established treatment for patients with heart failure with dyssynchrony. However, one-third of patients do not respond positively to it. Recently, multipoint pacing (MPP), which involves pacing from two sites on the left ventricle, has been found to improve symptoms and hemodynamics compared to conventional CRT. An automatic fused atrioventricular (AV) delay that performs fused pacing for intrinsic conduction has also been introduced. However, the combined effect of MPP and fused AV delay on acute hemodynamics is unknown. Objective: To evaluate the acute hemodynamic effects of MPP and fused AV delay in patients undergoing CRT. Methods: A pressure wire was delivered to the left ventricle, and dp/dt was compared with single atrial stimulation pacing in 52 patients with various pacing configurations. Results: < 0.001). Hemodynamic parameters significantly most improved with the combination of MPP and fused AV delay. Delta dp/dt was greater in LV pacing than in biventricular (BiV) pacing with MPP and fused AV delay; however, the delta QRS duration was shorter in LV pacing than in BiV pacing. Delta dp/dt and delta QRS duration were negatively correlated. The super-responder rate was 66%. Conclusion: Combining MPP and fused AV delay has an additional effect. Shortening the QRS duration can increase the dp/dt, but the estimated line differs between LV and BiV pacing.
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Miyamoto et al. (2025) conducted an observational in Heart failure with dyssynchrony undergoing CRT (n=52). Multipoint pacing (MPP) and fused AV delay vs. Single atrial stimulation pacing was evaluated on dp/dt (acute hemodynamics) (p=< 0.001). Combining multipoint pacing and fused AV delay significantly improved acute hemodynamic parameters (dp/dt) compared to single atrial stimulation pacing (P<0.001).
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