Key result
Hypertensive patients with high aldosterone:renin ratios had significantly increased plasma endothelin (5.1 vs 3.7 fmol/ml; P<0.03) and an endothelin-aldosterone interaction predicting urine protein.
Why the study?
Does the interaction between endothelin and aldosterone correlate with proteinuria in patients with low-renin hypertension?
Population
29 hypertensive patients, divided into those with high aldosterone:renin ratios and normal aldosterone:renin…
Comparison
Evaluation of endothelin, aldosterone, and… vs Hypertensive patients with normal…
Design
Cross-sectional
Authors
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Endothelin-aldosterone interaction may predict proteinuria in low-renin hypertension; supports experimental data but leaves therapeutic implications open.
Observational (n=29)
Does the interaction between endothelin and aldosterone correlate with proteinuria in patients with low-renin hypertension?
Absolute Event Rate: 5.1% vs 3.7%
p-value: p=< 0.03
An interaction between endothelin and aldosterone is a major predictor of proteinuria in low-renin hypertension, suggesting that combined antagonism may offer renal protection beyond blood pressure reduction.
Elijovich et al. (2004) conducted an observational in Low-renin hypertension (n=29). High aldosterone:renin ratio (HARR) vs. Normal aldosterone:renin ratio (NARR) was evaluated on Plasma endothelin concentration (fmol/ml) (p=< 0.03). Hypertensive patients with high aldosterone:renin ratios had significantly increased plasma endothelin (5.1 vs 3.7 fmol/ml; P<0.03) and an endothelin-aldosterone interaction predicting urine protein.
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