Key result
The isolated working heart model was successfully established in spontaneously hypertensive rats 8-12 weeks after coronary artery ligation, demonstrating reduced heart power and diminished contractility.
Population
Wistar Kyoto and spontaneously hypertensive rats with permanent occlusion of the left coronary artery to…
Design
Preclinical
Follow-up
8-12 weeks after coronary artery ligation
Authors
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Establishes isolated working heart model in post-MI hypertensive rats; leaves open translation to human HF therapies.
The isolated working heart model in spontaneously hypertensive rats with myocardial infarction provides a predictive preclinical model for studying end-stage heart failure and testing new therapeutic approaches.
Itter et al. (2005) studied Congestive heart failure and myocardial infarction. Permanent occlusion of the left coronary artery vs. Wistar Kyoto rats vs spontaneously hypertensive rats was evaluated on Evaluation of cardiodynamics (e.g., contractility) in the isolated working heart model. The isolated working heart model was successfully established in spontaneously hypertensive rats 8-12 weeks after coronary artery ligation, demonstrating reduced heart power and diminished contractility.
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