Key result
SHHF/Mcc-cp rats model human hypertensive-diabetic cardiomyopathy with ~100% congestive heart failure incidence.
Why the study?
Knowledge of the heart and cardiovascular system in genetic animal models of obesity and diabetes is limited, and the contributions of obesity, NIDDM, and hypertension to cardiovascular disease need clarification.
Population
SHHF/Mcc-cp rat model exhibiting obesity, non-insulin-dependent diabetes mellitus, and congestive heart failure
Design
Genetic animal model study
Authors
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Hypothesis-generating in mixed models; leaves open clinical translation in heart failure.
McCune et al. (1990) studied Obesity, Non-insulin-dependent Diabetes, and Congestive Heart Failure. SHHF/Mcc-cp rat model vs. Wistar Furth and Sprague Dawley rats was evaluated. The SHHF/Mcc-cp rat model exhibits hypertension (100%), obesity (25%), and congestive heart failure (100%), serving as a genetic model for human hypertensive-diabetic cardiomyopathy.
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