Key result
Systemic sclerosis was associated with left ventricular hypertrophy and/or diastolic impairment in 77% of patients, featuring significantly increased interventricular septum thickness (P=0.0001).
Why the study?
Does systemic sclerosis impair left ventricular diastolic function compared to healthy controls?
Population
30 consecutive patients with systemic sclerosis and 48 age- and sex-matched randomly sampled controls
Comparison
Systemic sclerosis (disease exposure) vs Age- and sex-matched randomly sampled controls
Design
Case-control
Authors
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Supports echocardiography in systemic sclerosis; hypothesis-generating for outcomes and interventions.
Case-Control (n=78)
Does systemic sclerosis impair left ventricular diastolic function compared to healthy controls?
Patients with systemic sclerosis frequently exhibit subclinical left ventricular hypertrophy and impaired diastolic filling even in the absence of systolic dysfunction.
Kazzam et al. (1990) conducted a case-control in Systemic sclerosis (n=78). Systemic sclerosis (exposure) vs. Age- and sex-matched randomly sampled controls was evaluated on Left ventricular hypertrophy and/or diastolic impairment. Systemic sclerosis was associated with left ventricular hypertrophy and/or diastolic impairment in 77% of patients, featuring significantly increased interventricular septum thickness (P=0.0001).
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