Why the study?
Does progressive systemic sclerosis impair left ventricular diastolic function compared to healthy volunteers?
Population
13 patients with progressive systemic sclerosis and 8 age-matched healthy volunteers
Comparison
Progressive systemic sclerosis (disease state) vs Age-matched healthy volunteers
Design
Case-control
Authors
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PSS-associated LV diastolic changes seen in case-control data; hypothesis-generating and should not yet alter practice.
Does progressive systemic sclerosis impair left ventricular diastolic function compared to healthy volunteers?
Patients with progressive systemic sclerosis exhibit deterioration of left ventricular diastolic function, which is most severe in those with disproportionate left ventricular wall thickening.
Fujimoto et al. (2008) studied this question.
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