What does this research mean for the field?

Female patients with systemic sclerosis who lack clinical signs of cardiovascular disease and have normal global ventricular function already exhibit impaired regional systolic and diastolic left ventricular myocardial function at rest and during exercise. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether regional left ventricular myocardial function is impaired in female systemic sclerosis patients who lack clinical cardiovascular signs and symptoms.

January 1, 2010Medicinski pregledOpen Access

Function of the left ventricular myocardium in patients with systemic sclerosis

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Why the study?

Does systemic sclerosis impair regional left ventricular myocardial function in female patients without clinical cardiovascular disease?

Population

44 females, comprising 23 patients with systemic sclerosis and 21 healthy controls.

Comparison

Pulsed wave tissue Doppler imaging at rest and… vs Healthy female controls undergoing the same…

Design

Case-control

Authors

MDMarina Deljanin-IlićUniversity of Nis SIStevan IlićUniversity of Nis BSBojana StamenkovićUniversity of Nis

Discussion

Member takes

Implication

Subclinical myocardial impairment is associated with systemic sclerosis; leaves open whether tissue Doppler screening improves risk stratification in asymptomatic patients.

Key Points

To determine whether regional left ventricular myocardial function is impaired in female systemic sclerosis patients who lack clinical cardiovascular signs and symptoms.
Assessed 23 female systemic sclerosis patients with normal global left ventricular function and 21 healthy female controls.
Performed pulsed wave tissue Doppler imaging to evaluate basal left ventricular myocardial segments at rest and during exercise stress echocardiography.
Patients with systemic sclerosis exhibited significantly reduced exercise test level and duration compared to controls (P < 0.001 for both).
Systemic sclerosis patients had significantly lower baseline regional systolic (P < 0.02) and diastolic (P < 0.001) myocardial function.
Functional reserve during exercise was blunted in systemic sclerosis patients, showing only a 20.6% systolic and 6.5% diastolic increase versus 32.3% and 25.0% in healthy controls.

Structured PICO

Does systemic sclerosis impair regional left ventricular myocardial function in female patients without clinical cardiovascular disease?

Population

44 females, comprising 23 patients with systemic sclerosis (without clinical signs and symptoms of cardiovascular disease and with normal global systolic and diastolic function of the left ventricle) and 21 healthy controls.

Intervention

Pulsed wave tissue Doppler imaging at rest and during exercise stress test echocardiography

Comparator

Healthy female controls undergoing the same imaging protocol

Outcome

Regional systolic and diastolic function of the left ventricular myocardium assessed from the basal segmentssurrogate

Pulsed wave tissue Doppler imaging reveals subclinical impairment of regional systolic and diastolic myocardial function in female patients with systemic sclerosis who have no overt cardiovascular disease.

Cite This Study

Deljanin-Ilić et al. (2010) studied this question.

synapsesocial.com/papers/6a1e7aa28a8a69122355ed8a https://doi.org/10.2298/mpns1004163d

Topics

Cardiomyopathy

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Implication

Subclinical myocardial impairment is associated with systemic sclerosis; leaves open whether tissue Doppler screening improves risk stratification in asymptomatic patients.

Function of the left ventricular myocardium in patients with systemic sclerosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Function of the left ventricular myocardium in patients with systemic sclerosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider