Short term follow-up of clinical outcome of patients with heart failure and associated hepatitis C virus infection

Background: There is increased risk of cardiovascular complications in hepatitis C virus (HCV)-infected patients regardless of the severity of the liver disease or the common cardiovascular risk factors. Aim of the Study: This study is conducted to evaluate the effect of associated hepatitis C viral infection on the short-term clinical outcome of acute decompensated heart failure (ADHF) patients during their in-hospital stay and one month after discharge.Patients and Methods: This is a prospective cohort study conducted on patients with ADHF, who were admitted in cardiovascular department at specialized medical hospital, Mansoura University during the period between January 2018 and January 2019. The study included 100 patients with heart failure (HF), 63 males and 37 females, and their ages ranged from 28 – 88 years.Results: There was no significant changes between heart failure (HF)patients with and without HCV regarding all demographic data, and HF risk factors. There was non-significant increase in prevalence of heart failure with reduced ejection fraction (HFrEF) among HF patients with HCV (70.3%) than without HCV (57.1% P>0.05). HCV infection had no significant effect on the outcome of HF clinical course, although, there was significant increase in prevalence of pulmonary hypertension in HF patients with HCV 35.1% than without HCV 11.1%.Conclusion: HCV-Infection in patients with ADHF has no effect on all aspects of patient’s clinical states. Among patients with ADHF, the main predictors of short-term post discharge clinical status are patient age and the whole duration of chronic HF disease.