Key result
Myocardial fibrosis mass and strain dyssynchrony index were independently associated with change in LVEF over 5 months of optimal medical therapy in newly diagnosed DCM (P≤0.001).
Why the study?
Are myocardial fibrosis by LGE-CMR and ventricular dyssynchrony by echocardiography independently associated with change in LVEF after 5 months of medical therapy in newly diagnosed idiopathic dilated cardiomyopathy?
Cohort (n=87)
Blinded to outcome
Are myocardial fibrosis by LGE-CMR and ventricular dyssynchrony by echocardiography independently associated with change in LVEF after 5 months of medical therapy in newly diagnosed idiopathic dilated cardiomyopathy?
p-value: p=≤0.001
In newly diagnosed idiopathic dilated cardiomyopathy, the extent of myocardial fibrosis by LGE-CMR and ventricular dyssynchrony are independent predictors of lack of LVEF improvement after 5 months of medical therapy.
No takes yet. Share an insight, caveat, or question.
Should not yet guide therapy in new DCM; leaves open whether fibrosis or dyssynchrony markers warrant targeted trials.
Leong et al. (2011) conducted a cohort in Idiopathic dilated cardiomyopathy (DCM) (n=87). Myocardial fibrosis (LGE-CMR) and ventricular dyssynchrony assessment vs. Healthy volunteers was evaluated on Change in LVEF over time (p=≤0.001). Myocardial fibrosis mass and strain dyssynchrony index were independently associated with change in LVEF over 5 months of optimal medical therapy in newly diagnosed DCM (P≤0.001).
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