What is the clinical evidence from this study?

Population: Myocardial infarction (n=9). Intervention: Modified DENSE MRI vs. Conventional tag analysis. Primary outcome: Circumferential (E(cc)) and radial (E(rr)) strain (R = 0.90).

What question did this study set out to answer?

This research aims to enhance myocardial function assessment through a modified DENSE MRI technique for infarct detection.

March 26, 2004Magnetic Resonance in Medicine

Complementary displacement‐encoded MRI for contrast‐enhanced infarct detection and quantification of myocardial function in mice

Q: What does this research mean for the field?

A modified DENSE MRI method employing complementary acquisitions provides T1-independent artifact suppression, enabling simultaneous measurement of myocardial strain and detection of contrast-enhanced infarcted myocardium in mice. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Modified DENSE MRI successfully measured myocardial strain and detected contrast-enhanced infarcted myocardium in mice, correlating well with conventional tag analysis (R = 0.90).

Key Points

This research aims to enhance myocardial function assessment through a modified DENSE MRI technique for infarct detection.
Developed a modified DENSE method with complementary acquisitions for T(1)-independent artifact suppression.
Conducted MRI scans on mice (N=9) before and after myocardial infarction (MI).
Measured circumferential and radial strain along with contrast-enhanced infarct detection using DENSE.
At baseline, circumferential strain (E(cc)) was -0.16 ± 0.01 and radial strain (E(rr)) was 0.39 ± 0.07.
After MI, E(cc) increased to 0.04 ± 0.02 and E(rr) was 0.03 ± 0.04 in infarcted regions.
DENSE E(cc) correlated well with conventional tag analysis (R = 0.90).

Structured PICO

Population

Mice before and after myocardial infarction (N=9)

Intervention

Modified DENSE MRI method employing complementary acquisitions for T1-independent artifact suppression

Comparator

Conventional tag analysis

Outcome

Circumferential (Ecc) and radial (Err) strain, and detection of contrast-enhanced infarcted myocardiumsurrogate

Main Result

Effect estimate: R = 0.90

A modified DENSE MRI technique allows for simultaneous measurement of myocardial strain and detection of contrast-enhanced infarcted myocardium in mice.

Discussion

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Implication

May enable preclinical combined strain-viability imaging; leaves open clinical translation pending validation.

Cite This Study

Gilson et al. (2004) studied Myocardial infarction (n=9). Modified DENSE MRI vs. Conventional tag analysis was evaluated on Circumferential (E(cc)) and radial (E(rr)) strain (R = 0.90). Modified DENSE MRI successfully measured myocardial strain and detected contrast-enhanced infarcted myocardium in mice, correlating well with conventional tag analysis (R = 0.90).

synapsesocial.com/papers/6a193f33ff42a97fac57fb99 https://doi.org/10.1002/mrm.20003

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Complementary displacement‐encoded MRI for contrast‐enhanced infarct detection and quantification of myocardial function in mice

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Complementary displacement‐encoded MRI for contrast‐enhanced infarct detection and quantification of myocardial function in mice

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

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