Why the study?
Does selective inducible NOS inhibition with SMT improve cardiopulmonary and peripheral circulatory effects compared to nonselective NOS inhibition with L-NAME or phenylephrine in endotoxic swine?
Does selective inducible NOS inhibition with SMT improve cardiopulmonary and peripheral circulatory effects compared to nonselective NOS inhibition with L-NAME or phenylephrine in endotoxic swine?
In an endotoxic swine model, selective inducible NOS inhibition with SMT showed better cardiopulmonary and gastric perfusion profiles than nonselective NOS inhibition with L-NAME, but was largely comparable to phenylephrine.
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Should not yet change sepsis management; leaves open advantages of selective iNOS inhibition over vasopressors in humans.
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Cohen et al. (2000) studied this question.
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