Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1982AJP Heart and Circulatory Physiology

Membrane properties of smooth muscle cells in pulmonary arteries of the rat

View Full Paper
Ask AI
Bookmark
Share

Population

Smooth muscle cells from rat main pulmonary artery (MPA) and small pulmonary artery (SPA)

Comparison

Electrophysiological and pharmacological stimuli vs Comparison between main pulmonary artery and…

Design

Preclinical

Authors

HSHiroyuki SuzukiBTBetty M. Twarog

Discussion

Loading...

Member takes

Overview

Vessel-specific ion responses in rat pulmonary arteries warrant caution against clinical extrapolation; leaves open translation to human pulmonary vascular disease.

Structured PICO

P
Population
Smooth muscle cells from rat main pulmonary artery (MPA) and small pulmonary artery (SPA)
I
Intervention
Electrophysiological and pharmacological stimuli (tetraethylammonium chloride, extracellular K+ changes, Na+-deficient solution)
C
Comparator
Comparison between main pulmonary artery (MPA) and small pulmonary artery (SPA)
O
Outcome
Electrical properties of the cell membrane (resting membrane potential, depolarization, hyperpolarization)surrogate

Rat main and small pulmonary arteries exhibit distinct electrophysiological membrane properties and responses to ion channel modulators.

Cite This Study

Suzuki et al. (1982) studied this question.

synapsesocial.com/papers/6a197ee6c05413006f586b4fhttps://doi.org/10.1152/ajpheart.1982.242.5.h900
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery1977 · 199 citations
  2. 2Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries2002 · 67 citations
  3. 3Electrical Quiescence of Pulmonary Artery Smooth Muscle During Sympathomimetic Stimulation1964 · 110 citations
  4. 4Some electrical properties of the endothelium‐dependent hyperpolarization recorded from rat arterial smooth muscle cells.1989 · 206 citations
  5. 5Effects of acetylcholine and catecholamines on the smooth muscle cell of the porcine coronary artery.1979 · 117 citations