Why the study?
Does nadolol alter noninvasive measurements of diastolic time intervals in patients with hypertrophic cardiomyopathy?
Does nadolol alter noninvasive measurements of diastolic time intervals in patients with hypertrophic cardiomyopathy?
Noninvasive measurement of diastolic time intervals does not appear useful for evaluating beta-blocker therapy in patients with hypertrophic cardiomyopathy.
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Nadolol showed no effect on diastolic intervals in this HCM case; leaves open utility of noninvasive measures for beta-blocker assessment.
In 9 patients with hypertrophic cardiomyopathy, diastolic function was evaluated by noninvasive measurements of diastolic time intervals before and after nadolol administration. No significant variation of the intervals was observed after therapy. The method therefore appears scarcely useful in the evaluation of beta-blocker therapy in these patients.
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Cecchi et al. (1986) studied this question.
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