Why the study?
Does angiotensin II induce endothelin-1 expression in vascular adventitial fibroblasts?
Population
Vascular adventitial fibroblasts isolated from mouse aorta
Design
Preclinical
Authors
Loading...
Adventitial fibroblasts may contribute to ANG II-driven ET-1 signaling; leaves open their role in remodeling pending in vivo and human validation.
Does angiotensin II induce endothelin-1 expression in vascular adventitial fibroblasts?
Vascular adventitial fibroblasts can synthesize and release ET-1 in response to ANG II, which may contribute to extracellular matrix synthesis via ETA receptors.
An et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: