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May 30, 2026Journal of Clinical Oncology

Prognostic associations of the G8 geriatric screening tool in the EORTC Brain Tumor Group trials 1608 and 1709 in patients with newly diagnosed glioblastoma.

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Authors

MWMichael WellerLBLuc BoonePRP. Roth

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Overview

Randomized trial assesses the G8 score's prognostic value in older glioblastoma patients, indicating its potential benefits for care planning.

Key Points

  • This study aims to evaluate the prognostic implications of the G8 screening tool in older glioblastoma patients enrolled in EORTC trials.
  • Analyzed data from 99 patients aged 70 or older in EORTC trials 1608 and 1709.
  • Defined G8 low group (<14) and high group (15-17) for analysis.
  • Considered Karnofsky performance status and treatment delivery metrics.
  • Patients in the G8 high group showed better overall survival (HR 0.67, 95% CI 0.42-1.07, p=0.096).
  • Higher Karnofsky status was significantly associated with the G8 high group (HR 5.44, 95% CI 2.17-14.46).
  • G8 high group had better treatment delivery metrics and lower toxicity rates.

Cite This Study

Weller et al. (2026) studied this question.

synapsesocial.com/papers/6a1a820e0307b78509433c44https://doi.org/10.1200/jco.2026.44.16_suppl.e13777
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1QOL-22. Prognostic associations of the G8 geriatric screening tool in the EORTC Brain Tumor Group trials 1608 and 1709 in newly diagnosed glioblastoma2025
  2. 2G8 screening-defined geriatric vulnerability as a predictor of survival and quality of life in older patients with advanced cancer treated with novel therapies.2026
  3. 3INNV-17. Diagnostic Performance and Prognostic Value of the G8 Screening Tool in Older Adults with Newly Diagnosed Glioblastoma, IDH Wild-Type2025
  4. 4G8 geriatric score as a determinant of survival and treatment in metastatic breast cancer.2026
  5. 5The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review2025 · 15 citations