Why the study?
Does mechanical circulatory support with an LVAD reduce myocardial TNF-alpha expression in patients with nonischemic end-stage cardiomyopathy?
Does mechanical circulatory support with an LVAD reduce myocardial TNF-alpha expression in patients with nonischemic end-stage cardiomyopathy?
Chronic mechanical circulatory support with an LVAD significantly decreases myocardial TNF-alpha expression in failing hearts, and the magnitude of this decrease may predict which patients will recover cardiac function.
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LVAD-linked TNF-alpha reduction may identify recovery candidates; leaves open its utility as weaning biomarker pending prospective trials.
Torre‐Amione et al. (1999) studied this question.
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