What does this research mean for the field?

Increased plasma renin activity, fasting serum insulin, and central obesity are independently associated with higher diastolic blood pressure, suggesting that plasma renin activity plays a key role in the development of obesity-induced hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1994American Journal of HypertensionOpen Access

Central Obesity and Hypertension: Relationship Between Fasting Serum Insulin, Plasma Renin Activity, and Diastolic Blood Pressure in Young Obese Subjects

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Population

61 young subjects, including normotensive and hypertensive subjects with central obesity, and lean…

Design

Cross-sectional

Authors

GLGiuseppe LicataUniversity of Messina RSRosario ScaglioneDepartment of Health AGAttilio GanguzzaUniversity of Palermo

Discussion

Member takes

Implication

May link insulin and renin to diastolic BP in central obesity; leaves open causal and clinical validation.

Structured PICO

Population

61 young (age < 40 years) subjects, including normotensive (n=27) and hypertensive (n=14) subjects with central obesity, and lean normotensives (n=20).

Comparator

Lean normotensive subjects

Outcome

Levels of plasma catecholamines, fasting serum insulin (IRI), urinary sodium excretion (NaU), plasma renin activity (PRA), and plasma aldosterone (PA), and their correlation with diastolic blood pressuresurrogate

Increased plasma renin activity and fasting serum insulin are significantly associated with higher diastolic blood pressure in young subjects with central obesity.

Cite This Study

Licata et al. (1994) studied this question.

synapsesocial.com/papers/6a1bcf23ea84844e355f00f9 https://doi.org/10.1093/ajh/7.4.314

Topics

Hypertension management

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Central Obesity and Hypertension: Relationship Between Fasting Serum Insulin, Plasma Renin Activity, and Diastolic Blood Pressure in Young Obese Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Central Obesity and Hypertension: Relationship Between Fasting Serum Insulin, Plasma Renin Activity, and Diastolic Blood Pressure in Young Obese Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider