Does cardiac metabolite and lipid substrate utilization differ between healthy subjects and subjects with HFpEF?
HFpEF is associated with altered cardiac metabolism, characterized by reduced fatty acid utilization and increased protein catabolism compared to healthy hearts.
The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.
O’Sullivan et al. (Wed,) studied this question.