Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction
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Why the study?
Does serum metabolomic profiling identify a unique biomarker fingerprint that can discriminate HFpEF from HFrEF and non-HF controls?
Population
82 ambulatory subjects including 24 with HFpEF, 20 with HFrEF, and 38 age-matched non-HF controls…
Comparison
Serum metabolomic profiling using combined… vs Age-matched non-HF controls and patients with…
Design
Cohort, Echocardiograms were interpreted by cardiologists blinded to the…
Authors
Discussion
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Implication
Metabolomic panels may enhance HFpEF discrimination when added to natriuretic peptides; hypothesis-generating and requires prospective validation before clinical adoption.
Structured PICO
Does serum metabolomic profiling identify a unique biomarker fingerprint that can discriminate HFpEF from HFrEF and non-HF controls?
P
Population
82 ambulatory subjects including 24 with HFpEF (LVEF >45%), 20 with HFrEF (LVEF ≤45%), and 38 age-matched non-HF controls. Exclusions included severe liver disease, end stage renal disease (GFR < 15 ml/min), active or ongoing malignancy, cardiac surgery, major surgery, or major cardiovascular event in the past 3 months.
I
Intervention
Serum metabolomic profiling using combined direct flow injection and LC-MS/MS and 1H-NMR spectroscopy to quantify 181 endogenous metabolites.
C
Comparator
Age-matched non-HF controls (individuals with normal LV function and no symptoms of HF) and patients with HFrEF (LVEF ≤45%).
O
Outcome
Identification of a metabolomic fingerprint/panel of metabolites to discriminate HFpEF patients from non-HF controls and HFrEF patients using logistic regression and area under the receiver operating characteristic (ROC) curves.surrogate
Cite This Study
Zordoky et al. (2015) studied this question.
Topics
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